Sulfonylurea receptor expression heterogeneity suggests chamber-specific roles for sarcolemmal KATP channels in heart.
نویسنده
چکیده
Late-Breaking Basic Science Abstracts: From the American Heart Association Scientific Sessions 2008, New Orleans, Louisiana, November 8–12, 2008 1493 Author Index 1502 On the cover: Image shows an epicardial explant from an embryonic day 12.5 PDGFR GFP mouse heart after 5 days in culture. Immunofluorescence for -catenin (red) demonstrates epicardial cell boundaries, and nuclear-localized green fluorescent protein (GFP; green) identifies cells expressing PDGFR . See related article, page 1393. by gest on July 2, 2017 http://circhajournals.org/ D ow nladed from
منابع مشابه
Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.
The isoform-specific structure of the ATP-sensitive potassium (K(ATP)) channel endows it with differential fundamental properties, including physiological activation and pharmacology. Numerous studies have convincingly demonstrated that the pore-forming Kir6.2 (KCNJ11) and regulatory SUR2A (ABCC9) subunits are essential elements of the sarcolemmal K(ATP) channel in cardiac ventricular myocytes....
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A variety of direct and indirect techniques have revealed the existence of ATP-sensitive potassium (KATP) channels in the inner membranes of mitochondria. The molecular identity of these mitochondrial KATP (mitoKATP) channels remains unclear. We used a pharmacological approach to distinguish mitoKATP channels from classical, molecularly defined cardiac sarcolemmal KATP (surfaceKATP) channels en...
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ATP-sensitive potassium (KATP) channels were first discovered in the heart 30 years ago. Reconstitution of KATP channel activity by coexpression of members of the pore-forming inward rectifier gene family (Kir6.1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein subfamily has led to the elucidation of many details of channel gating and por...
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BACKGROUND Opening of cardiac ATP-sensitive potassium channels (K(ATP) channels) is a well-characterized protective mechanism against ischemia and reperfusion injury. Evidence exists for an involvement of both sarcolemmal and mitochondrial K(ATP) channels in such protection. Classically, cardiac sarcolemmal K(ATP) channels are thought to be composed of Kir6.2 (inward-rectifier potassium channel...
متن کاملMolecular mechanisms of the inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on sarcolemmal adenosine triphosphate-sensitive potassium channels in the cardiovascular system.
BACKGROUND Sarcolemmal adenosine triphosphate-sensitive potassium (KATP) channels in the cardiovascular system may be involved in bupivacaine-induced cardiovascular toxicity. The authors investigated the effects of local anesthetics on the activity of reconstituted KATP channels encoded by inwardly rectifying potassium channel (Kir6.0) and sulfonylurea receptor (SUR) subunits. METHODS The aut...
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ورودعنوان ژورنال:
- Circulation research
دوره 103 12 شماره
صفحات -
تاریخ انتشار 2008